Given the significant sequelae, treatments that improve BV cure are needed. Recurrences negatively impact a woman’s quality of life and result in repeated clinical presentations and antibiotic use. First-line treatments have equivalent four-week cure rates of ~70–85%, but BV recurrence is common. Recommended first-line treatments for BV are oral or intravaginal metronidazole and intravaginal clindamycin. BV is associated with serious sequelae including miscarriage, preterm birth and pelvic inflammatory disease, and acquisition of sexually transmitted infections including HIV.

Vodstrcil, Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing 1, 2īacterial vaginosis (BV) is the commonest vaginal condition in reproductive aged women. Murray, Supervision, Visualization, Writing – review & editing, 3, 4, 5 Deborah Bateson, Visualization, Writing – review & editing, 6, 7 Lindi Masson, Visualization, Writing – review & editing, 1, 8, 9, 10, 11 Josephine Slifirski, Formal analysis, Investigation, Writing – review & editing, 2 Gilda Tachedjian, Methodology, Visualization, Writing – original draft, Writing – review & editing, 8, 12, 13 and Lenka A. Fairley, Supervision, Visualization, Writing – review & editing, 1, 2 Gerald L. Bradshaw, Conceptualization, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing, 1, 2 Michelle Doyle, Formal analysis, Investigation, Writing – review & editing, 2 Christopher K. Plummer, Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing, 1, 2, * Catriona S.

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